Stem Cell Transplant for Multiple Sclerosis (aHSCT)
Start watching to learn about how autologous hematopoietic stem cell transplant works for multiple sclerosis. How does it work? What are the different conditioning regimens (BEAM, cyotoxan, busulfan, ATG, etc)? What are the side effects? How does it compare to traditional disease modifying therapy?
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My book “Resilience in the Face of Multiple Sclerosis” on Amazon:
Sources:
HSCT review in general:
HSCT in MS review:
Swedish case series AHSCT in aggressive MS:
Pilot Study in progressive multiple sclerosis:
Canadian study in aggressive relapsing multiple sclerosis:
2010 registry for HSCT for autoimmune disease mortality stats:
Review of HSCT for MS mortality stats:
Professor Giovanoni’s blog-post on HSCT:
Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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The video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual’s medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.
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Great informative video Doc👏🏻👏🏻👏🏻👏🏻 thank you.
I just passed my one year diagnosis with MS and I've been on Tysabri for over a year . Possibly this could be an option for the future.
I wish you would discuss the opportunities for doing HSCT in America. It’s my understanding that it’s not available. What’s the safest way to investigate options abroad?
Very informative !! Could you please Dr, tell me if there is an age limit to undergo hsct is it risky for a 62year old patient thank you very much
Hopefully recent events haven't completely derailed the RAM-MS trial to compare HSCT to Lemtrada. If I fail on Lemtrada then I'd be eligible for HSCT on the public health system in my country, but I'm not sure my mother would approve of the 0.5% mortality rate…
Sometimes sometimes sometimes! 😬😔
Excellent video! This was the most informative explanation of aHSCT I have found. Thank you so much for putting this together. I wish all us MS'ers could get this procedure.
So Dr Beaber would you advise your patients with SPMS to pursue HSCT? I live in Australia and would have to travel overseas at enormous cost….
You’re right- I DO approve! Thank you for your thorough explanation about HSCT! Now if only you can get the NMSS to give HSCT (and Dr Burt) the credit they deserve! Best decision I ever made. #nochemonocure #DrBurtismyhero
This is the most thorough explanation I've heard to date. I am 3 months post AHSCT I went to Puebla Mexico to do it. I am extremely hopeful about it halting the disease and helping heal disability. I am an edss 6.5 currently
Hi again Dr Beaber. May I ask if I can link this video you have done to my MS Channel Anne’s MS Chronicles? I would be most grateful.
As I mentioned to you in your other video (about progression in remitting MS) when you asked me about the conditioning regime, I am an RN and am approached to support people who are newly diagnosed. As I have now sough out this treatment I have had a lot of people approach me about it. my channel is about scientific evidence, but mostly about my journey. i come at it from a nursing and personal perspective. I always think having a very science based video is a good thing. Investigating aHSCT needs to be part of an informed decision making process.
Hi Dr. Beaber, I regularly watch your amazing videos. As a MS sufferer for 10 years, I do not take drugs, but I'm very open to treatment with stem cells derived from donated umbilical cord tissue. Will you comment on this subject?
I started Alemtuzumab last year, it's going to work🙏🙏🙏 if it doesn't work my neurologist told me to try HSCT !
Neurologists may prescribe early "mini" HSCT, like Mavenclad. Today there are "safe" treatments to reboot the immune system !
The immune system comes back different now what happens to the damaged myelin?
How much would HSCT cost?
I’ve been waiting for this video for quite sometime. Thank you so much for your hard work to provide such an informative video.
I applaud you Dr Beaber. There are a lot of neurologists who are very resistant to even have a conversation about HSCT. I am in remission for the first time ever since having HSCT, something the 4 different DMTs were unable to achieve.
Completely agree with you about the misunderstanding in this instance about the role of the stem cells play. When I tell people about the treatment I had the impression is that the stem cells are somehow magic, that they reset the immune system, but it is the destruction of the immune system that is the backbone of this procedure.
loved it
loved it
wow, you are a hard-working man for your community. Thank you very much